TABLE 1.

Main pharmacokinetic parameters of TDS and 1-PP in rats (n = 6).

Parameter	Unit	TDS		1-PP
		i.g.	i.v.	i.g.	i.v.
AUC(0-t)	ng/mL*h	114.1 ± 41	48,375 ± 19,097	1,512 ± 238.4	4,201 ± 476
AUC(0-∞)	ng/mL*h	114.7 ± 41	48,397 ± 19,107	1879 ± 616.2	17,979 ± 12,674
MRT(0-t)	h	1.534 ± 0.30	0.516 ± 0.08	3.546 ± 1.19	4.523 ± 0.22
t 1/2	h	1.380 ± 0.46	1.224 ± 0.39	3.497 ± 3.64	29.498 ± 28.34
t max	h	0.161 ± 0.09	-	2.25 ± 1.47	1.3 ± 0.65
Vz/F	L/kg	412.841 ± 240.59	0.841 ± 0.42	47.261 ± 28.17	39.392 ± 14.47
CLz/F	L/h/kg	194.016 ± 69.01	0.476 ± 0.19	11.352 ± 2.64	1.686 ± 1.10
Cmax	ng/mL	83.23 ± 35.36	144,850 ± 86,523	357.2 ± 135.5	691.0 ± 82