Table 3.
Results in domains showing the greatest differences between AD patients and VaD subtypes.
VaD Subtype | Domain | k | n | [95% ETI] | Bayes factor | Newcastle-Ottawa scale | |||
---|---|---|---|---|---|---|---|---|---|
S | C | E | |||||||
VaD | Digit span backwards S, E, | 7 | 225 | 0.33 [0.12, 0.52] | 9.38 | 0.05 | 3 | 1 | 1 |
Delayed recall: Word list S, E | 4 | 235 | −0.61 [−0.97, −0.26] | 22.71 | 0.18 | 3 | 0 | 1 | |
Wechsler memory scale verbal recognition | 2 | 85 | −1.12 [−1.75, 0.04] | 4.72 | 0.42 | 3 | 1 | 1 | |
CERAD: Word list recognition | 4 | 228 | −0.92 [−1.38, −0.43] | 19.21 | 0.27 | 3 | 1 | 1 | |
Other measures of visual memoryS: Delayed recall | 5 | 177 | −0.85 [−1.29, −0.32] | 13.67 | 0.18 | 3 | 1 | 1 | |
Immediate visual associative memory | 4 | 354 | −1.01 [−1.49, −0.43] | 20.02 | 0.25 | 3 | 1 | 1 | |
sVaD | Phonemic fluency S, E, A, G | 17 | 1,460 | 0.51 [0.22, 0.77] | 42.36 | 0.40 | 3 | 1 | 1 |
Basic ADLS, E, A, G | 3 | 290 | −1.73 [−3.63, 0.01] | 4.14 | 1.92 | 3 | 0 | 1 | |
Graphical sequence test | 2 | 152 | 0.82 [0.02, 1.47] | 3.11 | 0.36 | 3 | 0 | 1 | |
Delayed recall: Prose | 4 | 670 | −0.70 [−1.12, −0.27] | 13.11 | 0.30 | 3 | 1 | 1 | |
Delayed recall: Word list S, E | 7 | 805 | −0.64 [−0.88, −0.36] | 72.97 | 0.18 | 3 | 1 | 1 | |
Discriminability in verbal memory | 4 | 489 | −0.76 [−1.26, −0.26] | 11.50 | 0.28 | 3 | 0 | 1 |
Positive effect sizes denote better performance of AD groups and are marked in bold. VaD, Vascular dementia; sVaD, Subcortical vascular dementia. Domain superscripts denote moderators included in the analyses: differences in average dementia severity (S), years of education (E), age (A) and proportion of women (G). k, Number of studies; n, Number of patients; 95% ETI, 95% equal-tailed credible interval. Newcastle-Ottawa-Scale Subscales medians: Selection (S), Comparability (C), Exposure (E). ADL, Activities of daily living. Standard deviation of random effects between studies. CERAD, Consortium to Establish a Registry for Alzheimer’s disease Test Battery.