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Key components from the lung microenvironment and lung tumor microenvironment. Abundant TGF-β, PGE2 and surfactant in the lung microenvironment are crucial for lung homeostasis. High oxygen and low glucose are special features of the lung microenvironment. When tumors grow in the lungs, more TGF-β and PGE2 are produced, and the physical and chemical environment changes to low oxygen, lower glucose, and low pH. Created with BioRender.com.
