. 2023 Nov 6;14:1222435. doi: 10.3389/fphar.2023.1222435

TABLE 4.

Summary of significant association between SNPs and incidence of specific ADRs.

SNP-ID	Gene	Genotype	Incidence of specific ADRs [n/N (%)]	Specific ADRs	p-Value
rs2231142	ABCG2	C/C	0/31 (0)	Myalgia	0.007 ^a
		C/A	0/27 (0)
		A/A	1/5 (20.0)
rs2622604	ABCG2	C/C	7/38 (18.4)	Diarrhea	0.011 ^a
		C/T	6/20 (30.0)
		T/T	4/5 (80.0)
rs762551	CYP1A2	C/C	1/3 (33.3)	Bullous dermatitis	0.006 ^a
		C/A	0/33 (0)
		A/A	0/27 (0)
CYP2A6 ^a 4	CYP2A6	non ^a 4/non ^a 4	12/54 (22.2)	Diarrhea	0.046 ^a
CYP2A6 ^a 4	CYP2A6	non ^a 4/ ^a 4	5/9 (55.6)	Diarrhea	0.046 ^a
rs1057910	CYP2C9	A/A	0/57 (0)	Acneiform rash grade 3	0.012 ^a
		A/C	0/5 (0)
		C/C	1/1 (100)
rs28371759	CYP3A4	A/A	11/60 (18.3)	QTc prolongation (%)	0.001 ^a
rs28371759	CYP3A4	A/G	3/3 (100.0)	QTc prolongation (%)	0.001 ^a

n, number of ADRs, in the genotype; N, number of all cases in the genotype; (%), incidence rate.

^{^a}

Statistically significant.