Table 1.

C. burnetii effector proteins in the intracellular proliferation

Virulence effector	Mechanism	Reference
Coxiella Vacuolar Protein A (CvpA)	Mechanism	( 33 )
Coxiella Vacuolar Protein B (CvpB)	Interacts with AP2, clathrin-mediated endocytosis (CME) adaptor that has been required for CHC accumulation at the CCVs.	( 28 )
Coxiella Vacuolar Protein C (CvpC)	Maintain LC3 on the CCVs membranes to aid fusion with autophagosomes.	( 34 )
Coxiella Vacuolar Protein D (CvpD)	Associated to the CCVs and required for its expansion.	( 35 )
Coxiella Vacuolar Protein E (CvpE)	Associated to the CCVs and required for its expansion.	( 28 )
Coxiella Vacuolar Protein F (CvpF)	Associated to the CCVs and required for its expansion.	( 28 )
Cig57 (CBU1751)	Interactions with Rab26 are required for C. burnetii-induced LC3 lipidation, CCVs formation, and LC3 delivery to the CCVs.	( 30 )