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. 2023 Jun 16;13(10):1153–1167. doi: 10.1016/j.jpha.2023.06.007

Fig. 2.

Fig. 2

Dioscin inhibits neuron viability and oxidative stress. (A) The histological changes of brain tissues after dioscin treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mice. (B) Western blotting of tyrosine hydroxylase (TH) in mice brain tissues after dioscin treatment on MPTP-induced PD mice (n = 3). (C) Immunohistochemistry assay of TH in mice brain tissues after dioscin treatment on MPTP-induced PD mice (n = 3). (D) Fluorescence semi-quantitative analysis of glial fibrillary acidic protein (GFAP) and ionized calcium bindingadaptor molecule-1 (IBA-1) expression in brain tissues after dioscin treatment on MPTP-induced PD mice (n = 3). (E) The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in brain tissues after dioscin treatment on MPTP-induced PD mice (n = 6). (F) The levels of glutathione (GSH)/glutathione disulfide (GSSG) and reactive oxygen species (ROS) in brain tissues after dioscin treatment on MPTP-induced PD mice (n = 6). Data are expressed as mean ± standard deviation (SD). ∗P < 0.05 and ∗∗P < 0.01 compared with MPTP group.