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. 2023 Jun 16;13(10):1153–1167. doi: 10.1016/j.jpha.2023.06.007

Fig. 3.

Fig. 3

Dioscin adjusts gut microbiota composition in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice. (A) Chao1 index of control, MPTP and MPTP + Dio80 groups. (B) The operational taxonomic unit (OTU) numbers of control, MPTP and MPTP + Dio80 groups. In general, if the similarity between sequences exceeds 97% (species level), it can be defined as an OTU, with each OTU representing a species. (C) Venn diagram illustrates the common and differential microbiota among control, MPTP and MTPT + Dio80 groups. (D) UniFrac distance-based principal coordinate analysis (PCA). (E) Distribution of relative abundance of gut microbiota at the phylum level observed in the control, MPTP and MPTP + Dio80 groups. (F) Relative abundance of microbiota at phylum in control, MPTP and MPTP + Dio80 groups. (G) Relative abundance of microbiota at class in control, MPTP and MPTP + Dio80 groups. (H) Relative abundance of microbiota at order in control, MPTP and MPTP + Dio80 groups. (I) Relative abundance of microbiota at genus level in control, MPTP and MPTP + Dio80 groups. (J) Fecal bile salt hydrolase (BSH) activity. Data are expressed as mean ± standard deviation (SD) (n = 6). ∗P < 0.05 and ∗∗P < 0.01 compared with MPTP group.