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. 2023 Jun 16;13(10):1153–1167. doi: 10.1016/j.jpha.2023.06.007

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Dioscin adjusts fecal metabolome by untargeted metabolomic analysis. (A) Principal components analysis (PCA) score plots for discriminating the fecal metabolome from control, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and MPTP + Dio groups. (B) Volcanic plot of differential metabolites among control, MPTP and MPTP + Dio groups. (C) Radar chart of differential metabolites among control, MPTP and MPTP + Dio groups. (D) Hierarchical clustering heat map of differential metabolites among control, MPTP and MPTP + Dio groups. (E) Some typical differential metabolites including cholic acid, deoxycholic acid, glycocholic acid, glycolithochilc acid, taurodeoxycholic acid, taurolithocholic acid, tauroursodeoxycholic acid and lithocholic acid among control, MPTP and MPTP + Dio groups. (F) Bubble plot of metabolites and significant pathway after dioscin treatment. (G) Tree map blot of metabolites and significant pathway after dioscin treatment. All data are given as mean ± standard deviation (SD) (n = 6). ^∗P < 0.05 and ^∗∗P < 0.01 compared with MPTP group.