Table 2.
Multivariable Cox regression for OS and BCSS.
| Variable | OS | BCSS | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | p-value | Hazard Ratio | 95% CI | p-value | |
| Age at diagnosis | ||||||
| ≤40 | 1.00 | Reference | 1.00 | Reference | ||
| 41-60 | 1.18 | 1.10-1.27 | <0.001 | 1.16 | 1.08-1.25 | <0.001 |
| 61-80 | 1.42 | 1.32-1.52 | <0.001 | 1.32 | 1.23-1.43 | <0.001 |
| >80 | 2.15 | 1.98-2.33 | <0.001 | 1.86 | 1.71-2.03 | <0.001 |
| Sex | ||||||
| Female | 1.00 | Reference | 1.00 | Reference | ||
| Male | 1.18 | 1.02-1.37 | 0.03 | 1.19 | 1.01-1.39 | 0.35 |
| Race | ||||||
| White | 1.00 | Reference | 1.00 | Reference | ||
| Black | 1.37 | 1.35–1.39 | <0.001 | 1.30 | 1.24-1.36 | <0.001 |
| Other | 0.94 | 0.89-1.00 | 0.07 | 0.95 | 0.89-1.02 | 0.14 |
| Unknown | 0.39 | 0.25-0.61 | <0.001 | 0.41 | 0.26-0.66 | <0.001 |
| Year of diagnosis | 0.98 | 0.97-0.99 | <0.001 | 0.98 | 0.97-0.98 | <0.001 |
| Tumor size | ||||||
| T0 | 1.00 | Reference | 1.00 | Reference | ||
| T1 | 1.33 | 1.17-1.52 | <0.001 | 1.40 | 1.21-1.61 | <0.001 |
| T2 | 1.49 | 1.31-1.69 | <0.001 | 1.57 | 1.37-1.80 | <0.001 |
| T3 | 1.60 | 1.40-1.82 | <0.001 | 1.70 | 1.48-1.96 | <0.001 |
| T4 | 1.82 | 1.60-2.06 | <0.001 | 1.92 | 1.68-2.21 | <0.001 |
| Unknown | 1.82 | 1.57-2.10 | <0.001 | 1.91 | 1.64-2.24 | <0.001 |
| Node positivity | ||||||
| N0 | 1.00 | Reference | 1.00 | Reference | ||
| N1 | 0.98 | 0.93-1.02 | 0.27 | 0.99 | 0.94-1.04 | 0.64 |
| N2 | 1.05 | 0.99-1.12 | 0.11 | 1.08 | 1.01-1.15 | 0.03 |
| N3 | 1.05 | 1.00-1.12 | 0.07 | 1.07 | 1.01-1.14 | 0.03 |
| Unknown | 1.23 | 1.14-1.33 | <0.001 | 1.21 | 1.12-1.31 | <0.001 |
| Grade | ||||||
| I | 1.00 | Reference | 1.00 | Reference | ||
| II | 1.21 | 1.13-1.31 | <0.001 | 1.26 | 1.16-1.37 | <0.001 |
| III | 1.64 | 1.52-1.78 | <0.001 | 1.76 | 1.62-1.91 | <0.001 |
| IV | 1.57 | 1.23-2.00 | <0.001 | 1.67 | 1.29-2.15 | <0.001 |
| Unknown | 1.42 | 1.31-1.54 | <0.001 | 1.50 | 1.38-1.64 | <0.001 |
| Histology | ||||||
| IDC 8500/3 | 1.00 | Reference | 1.00 | Reference | ||
| ILC 8520/3 | 1.10 | 1.04-1.17 | 0.001 | 1.13 | 1.07-1.20 | <0.001 |
| Mixed IDC/ILC 8522/3 | 1.02 | 0.94-1.10 | 0.68 | 1.04 | 0.95-1.13 | 0.44 |
| Other types | 1.07 | 1.02-1.13 | 0.01 | 1.06 | 1.00-1.12 | 0.04 |
| Hormone receptor | ||||||
| HR+/HER2- | 1.00 | Reference | 1.00 | Reference | ||
| HR+/HER2+ | 0.89 | 0.84-0.93 | <0.001 | 0.88 | 0.83-0.93 | <0.001 |
| HR-/HER2+ | 1.18 | 1.10-1.26 | <0.001 | 1.17 | 1.09-1.25 | <0.001 |
| HR-/HER2- | 2.63 | 2.51-2.77 | <0.001 | 2.69 | 2.56-2.84 | <0.001 |
| Surgery | ||||||
| Yes | 1.00 | Reference | 1.00 | Reference | ||
| No | 1.85 | 1.78-1.93 | <0.001 | 1.91 | 1.81-2.00 | <0.001 |
| Unknown | 1.63 | 1.32-2.02 | <0.001 | 1.72 | 1.38-2.14 | <0.001 |
| Radiation | ||||||
| Yes | 1.00 | Reference | 1.00 | Reference | ||
| No/Unknown | 1.00 | 0.96-1.03 | 0.91 | 0.97 | 0.93-1.01 | 0.09 |
| Chemotherapy | ||||||
| Yes | 1.00 | Reference | 1.00 | Reference | ||
| No/Unknown | 1.57 | 1.51-1.63 | <0.001 | 1.54 | 1.48-1.61 | <0.001 |
IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma.