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GKRP inhibition of GK activity in the p.V91L and p.S69_E70insVPL GCK-HI mutants. GK enzyme activity of GK mutants (p.V91L and p.S69_E70insVPL) was assessed in the presence of different molar ratio of GK to GKRP (1:1 and 1:2) at glucose (G) concentrations of 3 mmol/L (A and D), 6 mmol/L (B and E), and 12 mmol/L (C and F). The error bars represent ± SEM. Statistics were calculated using single-factor ANOVA (n = 4–5). *P < 0.001; #P < 0.05 compared with WT.
