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. 2023 Nov 19;13:20230. doi: 10.1038/s41598-023-47539-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Volcano plots for 88 different sphingolipids, with individual sphingolipids shown as individual dots, for comparisons healthy controls versus PACS + POTS patients (A), healthy controls versus PACS-POTS patients (B) and PACS-POTS versus PACS + POTS patients (C). Non-significant (grey) and significant (red) changes are shown. Adjusted p < 0.05 was considered statistically significant.