Table 1. Lipid profile of SHR, SHRApoE(−/−) and SHRApoE(−/−)Prdx2(−/−) under normal chow or HFD.
| SHR | SHRApoE(−/−) | SHRApoE(−/−)Prdx2(−/−) | P | ||
|---|---|---|---|---|---|
| (A) MF | N | 3 | 7 | 7 | |
| TC (mg/dl) | 63.3 ± 2.7 | 171.7 ± 28.7 | 172.4 ± 13.4 | <0.01*† | |
| HDL-C (mg/dl) | 45.6 ± 1.3 | 23 ± 1.3 | 23.1 ± 1.3 | <0.01*† | |
| TG (mg/dl) | 43.1 ± 6.1 | 131.9 ± 41.8 | 127.4 ± 23.8 | <0.01*† | |
| (B) HFD | N | 3 | 7 | 7 | |
| TC (mg/dl) | 73 ± 2.2 | 710.4 ± 77.9 | 680.6 ± 104.0 | <0.01*† | |
| HDL-C (mg/dl) | 44 ± 1.8 | 41.9 ± 15.4 | 61.1 ± 16.0 | n.s. | |
| TG (mg/dl) | 40.9 ± 3.6 | 98.9 ± 36.2 | 82.8 ± 19.0 | <0.01† | |
Male rats at 12 weeks of age were fed normal chow or HFD. After 8 weeks of feeding, serum samples were taken and total cholesterol (TC), high density lipoprotein cholesterol (HDL-C)) and triglyceride (TG) were measured as described in Methods. Each value represents mean ± SD. *: SHR vs. SHRApoE(−/−), †: SHR vs. SHRApoE(−/−)Prdx2(−/−). No significant differences were observed between SHRApoE(−/−) and SHRApoE(−/−)Prdx2(−/−).