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. 2023 Nov 6;10:1258902. doi: 10.3389/fmolb.2023.1258902

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Copyright © 2023 Martin-Hernandez, Espeso-Gil, Domingo, Latorre, Hervas, Hernandez Mora and Kotelnikova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integrative network consisting of genes and micro RNA’s identified in the multi-omics signature, their topological regulators and ontologies (nodes), and their relationships (edges). The nodes of the network were restricted to all the genes from the multi-omics signature and their regulators showing at least one interaction. Only micro RNA’s with at least five interactions are shown. Important ontologies in the network are enriched for multi-omics biomarkers (p-value≤0.01) and include at least 1 regulator. Regarding the edges of the network, two types of connections are considered: 1) Protein-Protein interactions among multi-omics biomarkers and their topological regulators, 2) Protein-Part of pathway, in which multi-omics biomarkers and their topological regulators belong or not to the aforementioned ontologies.