TABLE 7.
Univariate and multivariate cox regression results for survival analysis. The features below are included in the multi-omics signature and were also available in the validation dataset (GSE49280).
| Feature | Unadjusted | Adjusted | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| HAUS8 | 0.09 (0.03–0.32) | 0 | 0.18 (0.05–0.71) | 0.01 |
| hsa-mir-1258 | 14.93 (3.36–66.37) | 0 | 7.27 (1.56–33.89) | 0.01 |
| SHB | 0.18 (0.06–0.56) | 0 | 0.32 (0.1–0.98) | 0.05 |
| UBE2S | 0.21 (0.08–0.57) | 0 | 0.36 (0.12–1.13) | 0.08 |
| DDX39A | 0.17 (0.06–0.48) | 0 | 0.38 (0.12–1.22) | 0.1 |
| PLXNA1 | 0.23 (0.08–0.64) | 0.01 | 0.19 (0.06–0.58) | 0 |
| hsa-mir-376c | 0.22 (0.07–0.65) | 0.01 | 0.31 (0.1–0.99) | 0.05 |
| hsa-mir-504 | 0.28 (0.1–0.78) | 0.01 | 0.34 (0.11–1.06) | 0.06 |
| TSPYL4 | 0.24 (0.09–0.68) | 0.01 | 0.38 (0.13–1.1) | 0.07 |
| hsa-mir-615 | 0.16 (0.04–0.7) | 0.01 | 0.31 (0.07–1.39) | 0.13 |
| N4BP2L1 | 3.41 (1.28–9.08) | 0.01 | 1.72 (0.55–5.41) | 0.35 |
| DCAF15 | 0.3 (0.11–0.79) | 0.01 | 0.73 (0.25–2.17) | 0.58 |
| cg25836301 | 2.53 (1.13–5.64) | 0.02 | 5.41 (2.2–13.3) | 0 |
| hsa-mir-874 | 3.04 (1.21–7.61) | 0.02 | 2.75 (1–7.53) | 0.05 |
| SNORD113-3 | 0.3 (0.11–0.79) | 0.02 | 0.37 (0.13–1.03) | 0.06 |
| hsa-mir-381 | 0.3 (0.11–0.8) | 0.02 | 0.46 (0.16–1.31) | 0.15 |
| B4GALT3 | 0.29 (0.1–0.81) | 0.02 | 0.47 (0.16–1.37) | 0.17 |
| DUSP12 | 0.31 (0.12–0.82) | 0.02 | 0.57 (0.21–1.54) | 0.27 |
| MEG9 | 0.35 (0.13–0.93) | 0.03 | 0.39 (0.14–1.04) | 0.06 |
| GATA4 | 0.34 (0.13–0.89) | 0.03 | 0.49 (0.18–1.36) | 0.17 |
| hsa-mir-5690 | 3.94 (1.14–13.61) | 0.03 | 1.52 (0.4–5.72) | 0.54 |
| KANSL1-AS1 | 2.85 (1.02–7.94) | 0.04 | 1.57 (0.55–4.53) | 0.4 |
| hsa-mir-487b | 0.36 (0.13–1.01) | 0.05 | 0.42 (0.15–1.2) | 0.11 |
| CLMP | 0.39 (0.15–1) | 0.05 | 0.74 (0.26–2.07) | 0.56 |
| TUBB4B | 0.37 (0.14–0.99) | 0.05 | 0.88 (0.27–2.9) | 0.84 |
| SNORD114-3 | 0.44 (0.17–1.12) | 0.08 | 0.5 (0.19–1.33) | 0.17 |
| ZUP1 | 0.43 (0.17–1.11) | 0.08 | 0.65 (0.24–1.72) | 0.38 |
| C11orf1 | 2.15 (0.84–5.48) | 0.11 | 2.26 (0.81–6.31) | 0.12 |
| FRAT2 | 0.46 (0.18–1.19) | 0.11 | 0.53 (0.2–1.39) | 0.19 |
| MIR770 | 0.48 (0.19–1.23) | 0.13 | 1 (0.35–2.85) | 0.99 |
| hsa-mir-466 | 2.15 (0.77–5.97) | 0.14 | 1.62 (0.57–4.65) | 0.37 |
| MEG3 | 0.52 (0.2–1.33) | 0.17 | 0.57 (0.21–1.54) | 0.27 |
| hsa-mir-181d | 1.84 (0.74–4.59) | 0.19 | 1.34 (0.51–3.51) | 0.55 |
| VWA5B2 | 1.7 (0.67–4.33) | 0.26 | 2.82 (1.08–7.36) | 0.03 |
| cg16488098 | 0.64 (0.27–1.54) | 0.32 | 0.74 (0.3–1.78) | 0.5 |
| hsa-mir-511 | 2.08 (0.48–9.05) | 0.33 | 0.76 (0.16–3.59) | 0.73 |
| SIAE | 1.55 (0.63–3.84) | 0.34 | 0.93 (0.35–2.52) | 0.89 |
| YJEFN3 | 0.66 (0.27–1.65) | 0.38 | 0.66 (0.25–1.78) | 0.42 |
| ST6GALNAC4 | 0.66 (0.27–1.66) | 0.38 | 0.7 (0.28–1.77) | 0.45 |
| GALNS | 0.67 (0.27–1.67) | 0.39 | 0.62 (0.24–1.57) | 0.31 |
| cg25063710 | 1.4 (0.62–3.16)) | 0.42 | 1.08 (0.47–2.46) | 0.86 |
| hsa-mir-216a | 1.43 (0.58–3.51) | 0.44 | 1.23 (0.49–3.05) | 0.66 |
| JTB | 1.43 (0.58–3.58) | 0.44 | 0.9 (0.34–2.35) | 0.83 |
| PAQR5 | 0.7 (0.28–1.76) | 0.46 | 0.71 (0.26–1.93) | 0.51 |
| ASF1A | 1.41 (0.57–3.53) | 0.46 | 0.92 (0.36–2.35) | 0.86 |
| CLASRP | 0.74 (0.3–1.83) | 0.51 | 0.62 (0.23–1.7) | 0.35 |
| hsa-mir-217 | 1.35 (0.54–3.37) | 0.52 | 1.12 (0.44–2.88) | 0.81 |
| hsa-mir-4521 | 0.74 (0.29–1.89) | 0.53 | 1.38 (0.52–3.69) | 0.52 |
| KCNJ14 | 1.34 (0.54–3.34) | 0.53 | 1.08 (0.43–2.7) | 0.88 |
| STAC3 | 1.23 (0.5–3.05) | 0.65 | 1.34 (0.53–3.39) | 0.53 |
| CAP2 | 1.23 (0.5–3.02) | 0.66 | 0.9 (0.35–2.34) | 0.84 |
| RNPEP | 0.82 (0.33–2.02) | 0.67 | 0.37 (0.14–0.99) | 0.05 |
| hsa-mir-3912 | 1.17 (0.47–2.91) | 0.74 | 1.41 (0.54–3.69) | 0.48 |
| UGGT2 | 0.87 (0.35–2.14) | 0.76 | 0.98 (0.39–2.47) | 0.96 |
| hsa-mir-1179 | 1.13 (0.46–2.79) | 0.79 | 1.06 (0.42–2.69) | 0.9 |
| hsa-mir-4326 | 0.9 (0.36–2.23) | 0.81 | 1.48 (0.57–3.83) | 0.42 |
| CHID1 | 0.91 (0.37–2.24) | 0.83 | 0.78 (0.31–1.95) | 0.59 |
| AVPR1A | 1.1 (0.45–2.72) | 0.83 | 0.81 (0.31–2.16) | 0.68 |
| hsa-mir-190b | 1.1 (0.44–2.75) | 0.83 | 0.91 (0.35–2.39) | 0.85 |
| ACSS2 | 1.08 (0.43–2.69) | 0.87 | 1.13 (0.44–2.92) | 0.8 |
| TEDC1 | 1.07 (0.43–2.64) | 0.88 | 1.47 (0.57–3.76) | 0.43 |
| D2HGDH | 1.06 (0.43–2.62) | 0.9 | 0.81 (0.3–2.23) | 0.69 |
| PRELID3A | 1 (0.4–2.45) | 0.99 | 0.66 (0.25–1.7) | 0.39 |