Table 1.
Baseline demographics and disease characteristics of patients with C3G (N = 8)a
| Demographic Characteristics | |
|---|---|
| Sex, n (%) | |
| Male | 3 (37.5) |
| Female | 5 (62.5) |
| Age, mean (SD), yr | 22.5 (8.7) |
| Weight, mean (SD), kg | 76.6 (15.6) |
| Body mass index, n = 7; mean (SD), kg/m2 | 24.9 (5.9) |
| Race, n (%) | |
| Black/African American | 1 (12.5) |
| White | 6 (75.0) |
| Otherb | 1 (12.5) |
| Disease characteristics, mean (SD) | |
| Time since diagnosis, yr | 8.6 (7.6) |
| UPCR from 24-hour urine, mg/mg | 3.3 (1.7) |
| Mean of the 3 spot UPCR, n = 6; mg/mg | 1.8 (0.8) |
| Total protein from 24-hour urine, mg/d | 5026.5 (2717.1) |
| eGFR, ml/min per 1.73 m2c | 102.4 (45.5) |
| Serum albumin, g/dld | 3.3 (0.7) |
| Serum creatinine, mg/dle | 1.2 (1.0) |
| Systolic blood pressure, mm Hg | 127.6 (13.2) |
| Diastolic blood pressure, mm Hg | 77.4 (8.8) |
| Serum C3, mg/dlf | 44.0 (42.3) |
| Serum C4, mg/dlg | 18.5 (7.3) |
| Plasma sC5b-9, n = 7; μg/lh | 1337.1 (1382.7) |
| C3 nephritic factor, n (%)i | |
| Not detected | 7 (87.5) |
| Detected | 1 (12.5) |
| Concomitant medications, n (%) | |
| RAS blockers | 8 (100) |
| Systemic corticosteroids | 3 (37.5) |
| Immunosuppressantsj | 5 (62.5) |
| Mycophenolate mofetil | 5 (62.5) |
| Cyclosporin | 0 |
| Belimumab | 0 |
| Tacrolimus | 0 |
| Antibacterials | 7 (87.5) |
| Lipid-modifying agents | 4 (50) |
| Antithrombic/antiplatelet | 0 |
| Prior medications, n (%) | |
| RAS blockers | 8 (100) |
| Systemic corticosteroids | 4 (50) |
| Immunosuppressantsj | 5 (62.5) |
| Mycophenolate mofetil | 5 (62.5) |
| Cyclosporin | 0 |
| Belimumab | 0 |
| Tacrolimus | 0 |
| Antibacterials | 3 (37.5) |
| Lipid-modifying agents | 3 (37.5) |
| Antithrombic/antiplatelet | 0 |
C3G, C3 glomerulopathy; eGFR, estimated glomerular filtration rate; RAS, renin-angiotensin system; sC5b-9, soluble C5b-9; SD, standard deviation; UPCR, urine protein-to-creatinine ratio.
Number of patients unless mentioned otherwise.
Other than American Indian or Alaskan Native, Asian, Native Hawaiian, or other Pacific islander.
eGFR reference value: ≥60 ml/min per 1.73 m2.
Serum albumin reference range: 3.5–5.5 g/dl.
Serum creatinine reference range: 0.74–1.35 mg/dl for adult men and 0.59–1.04 mg/dl for adult women.
C3 reference range: 90–180 mg/dl.
C4 reference range:10–40 mg/dl.
sC5b-9 normal range: 72–244 μg/l.
Patients with C3 nephritic factor (ratio of C3 fragment to intact C3) >0.33 were considered to have a detectable value.
Does not include corticosteroids.