Figure 4.

Distribution of the predicted mGFR at given eGFR cut-off points. To enable clinical decision making, this figure depicts the range of predicted mGFR of a patient with a given eGFR using the CKD staging cut-off points. The mGFR was predicted using a model created using quintile regression of each of the 4 equations PENK-Crea, MDRD, 2009 CKD-EPI and 2021 CKD-EPI. The Box Plots represent quantiles (minimum, first quartile, median, third quartile, and maximum) of each equation. The performance of an equation is better when the median of the predicted mGFR is closest to the given eGFR cut-off points, and when the distribution of the predicted mGFR is more narrow at that eGFR cut-off point. As an example, with an eGFR of 60 ml/min/1.73 m² calculated with the PENK-Crea equation, 95% of the mGFR’s will be in the range of 34–88. While an eGFR of 60 calculated with the MDRD equation, 95% of the mGFR’s will be between the range of 37–104. mGFR or eGFR: measured or estimated glomerular filtration rate. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; MDRD, Modification of Diet in Renal Disease.