Table 5.
Causal mediation analysis of suPAR on all-cause death, cardiovascular death, and MACE
| Variables | Mediator | Estimate, (95% CI) |
|||
|---|---|---|---|---|---|
| Total effect | ACME | ADE | Proportion Mediated | ||
| All-cause death | eGFR | 0.0431 (0.0283; 0.0579) | 0.0012 (−0.0011; 0.0035) | 0.0419 (0.0275; 0.0566) | 0.0274 (−0.0290; 0.0927) |
| UACR | 0.0412 (0.0270; 0.0548) | 0.0017 (0.0003; 0.0031) | 0.0395 (0.0250; 0.0538) | 0.0402 (0.0079; 0.0845) | |
| CV death | eGFR | 0.0123 (0.0049; 0.0191) | 0.0014 (0.00001; 0.0029) | 0.0109 (0.0032; 0.0178) | 0.1115 (0.0004; 0.3531) |
| UACR | 0.0121 (0.0051; 0.0189) | 0.0007 (−0.0002; 0.0017) | 0.0114 (0.0045; 0.0184) | 0.0576 (−0.0181; 0.2014) | |
| MACE | eGFR | 0.0169 (0.0037; 0.0303) | 0.0019 (−0.0005; 0.0046) | 0.0150 (0.0014; 0.0287) | 0.1090 (−0.0317; 0.5965) |
| UACR | 0.0165 (0.0036; 0.0301) | 0.0015 (0.0001; 0.0030) | 0.0165 (0.0036; 0.0301) | 0.0904 (0.0039; 0.4151) | |
ACME, average causal mediation effect; ADE, average direct effect; CI, confidence interval; CV, cardiovascular; eGFR, estimated glomerular filtration rate; MACE, major adverse cardiovascular events; suPAR, soluble urokinase plasminogen activator receptor; UACR, urine albumin-to-creatinine ratio.
The model included age, gender, body-mass index, current smoking, hypertension, diabetes mellitus, low-density lipoprotein levels, high-density lipoprotein levels, coronary artery disease, stroke, peripheral arterial disease, phosphate and intact parathormone.