Table 1.

Acquisition details for T2-weighted, T2∗-weighted and diffusion-weighted MRI (dMRI)

MRI modality	Acquisition time	Resolution/Matrix size	Acquisition parameters
T2-weighted	33 min	60 × 60 × 60 μm/400 × 160 × 200	TurboRARE, TE = 12 ms, echo spacing = 12 ms, 6 echoes, TR = 350 ms, BW = 60 kHz
T2∗-weighted	26 min	100 × 100 × 100 μm/240 × 96 × 120	3D Multi-echo GRE, FA = 15°, TE1 = 3 ms, echo spacing = 3 ms, 20 echoes, TR = 68 ms, NR = 2, BW = 250 kHz
dMRI	13 h	100 × 100 × 100 μm/240 × 96 × 120	Segmented EPI, 12 segments, TE = 30 ms, TR = 500 ms, δ/Δ = 6.7/13.5 ms, b = 0 s/mm2 (volumes: 4 + 1 phase-encoding reversed), b = 2500 s/mm2 (volumes: 30), b = 10000 s/mm2 (volumes: 30), BW = 250 kHz, directions covering the whole shell and staggered between shells

Turbo Rapid Acquisition with Relaxation Enhancement (RARE), echo time (TE), repetition time (TR), bandwidth (BW), gradient echo (GRE), flip angle (FA), number of repetitions (NR), echo-planar imaging (EPI), duration of the diffusion-encoding gradient (δ), time interval between the two diffusion-encoding gradients (Δ), and b-value (b).