Table 2.
Zinc and iron intake-attributed differences in likelihood of progression of tibial trabecular sclerosis in OA knees.
| Exposure | Unadjusted estimate: β (95%CI) P value | Adjusted estimate*: β (95%CI) P value |
|---|---|---|
| Zinc | ||
| BV/TV | 0.988 (0.969, 1.008) 0.24010 | 0.983 (0.957, 1.011) 0.23136 |
| Tb.N | 0.980 (0.960, 1.000) 0.04976 | 0.967 (0.939, 0.996) 0.02632 |
| Tb.Th | 0.981 (0.961, 1.000) 0.04990 | 0.958 (0.929, 0.989) 0.00767 |
| Tb.Sp | 0.986 (0.966, 1.007) 0.20417 | 0.959 (0.928, 0.991) 0.01319 |
| Iron | ||
| BV/TV | 1.001 (0.987, 1.016) 0.85808 | 1.007 (0.988, 1.026) 0.49803 |
| Tb.N | 1.005 (0.991, 1.020) 0.48708 | 1.011 (0.992, 1.030) 0.26524 |
| Tb.Th | 1.000 (0.985, 1.014) 0.96539 | 1.000 (0.981, 1.019) 0.96010 |
| Tb.Sp | 1.012 (0.997, 1.027) 0.13143 | 1.009 (0.989, 1.028) 0.37549 |
Estimates represent a mean difference in the likelihood of progression of subchondral sclerosis for every additional 1 mg/1000 kcal of zinc or iron intake.
*Adjusted for age, sex, race, BMI, Kellgren-Lawrence (KL) grade, and PASE score, alcohol use, smoking status, history of bone fracture after the age of 45, history of hip fracture, history of vertebral/spine fracture, history of oral corticosteroid medication use, history of bisphosphonate intake, intact parathyroid hormone level, serum 25-vitamin D level and calcium and magnesium intake.