Table 1.
Assessment schedule of hospitalized patients in DIRECT study
| Clinical data | Hospital admission | Pre-drug exposure | Drug exposure | AKI onset | Peak SCr or peak severity of injury | Drug discontin uation | Nadir SCr or resolution of injury | Hospital discharge | Status at days 28 and 90 |
|---|---|---|---|---|---|---|---|---|---|
| Physical exam | X | X | X | X | X | X | X | X | |
| AKI risk factors | X | X | X | X | X | X | X | X | |
| Vital signs | X | X | X | X | X | X | X | X | |
| Laboratory tests | X | X | X | X | X | X | X | X | |
| SCr | X | X | X | X | X | X | X | X | X |
| Urine study | X | ||||||||
| KRT | X | X | X | X | X | X | |||
| Survival status | X | X |
AKI, acute kidney injury; KRT, kidney replacement therapy; SCr, serum creatinine.
Peak SCr or peak severity of injury was defined as the highest SCr recorded throughout hospitalization.
This table was adapted from Awdishu et al.12 “Rationale and design of the genetic contribution to Drug Induced Renal Injury (DIRECT) study.” Kidney Int Rep. 2016;1:288-298.