TABLE 1.
Modified clinical activity index (MCAI) scoring system used as the primary endpoint for evaluating the clinical response to a daily IV administration of fuzapladib or placebo for 3 consecutive days to dogs with acute pancreatitis (AP).
| Variable | Score | Description |
|---|---|---|
| Activity | 0 | Normal (as usual) |
| 1 | Slightly decreased (stands less than usual) | |
| 2 | Moderately decreased (is reluctant to stand) | |
| 3 | Severely decreased (cannot stand up) | |
| Appetite a | 0 | Normal (ate more than ¾ of food offered) |
| 1 | Slightly decreased (ate about ½ of food offered) | |
| 2 | Moderately decreased (ate about ¼ of food offered) | |
| 3 | Severely decreased (did not eat or not much of the food offered) | |
| Vomiting | 0 | None |
| 1 | 1‐2 times/day | |
| 2 | 3‐4 times/day | |
| 3 | ≥ 5 times/day | |
| Cranial abdominal pain | 0 | None (no signs of pain) |
| 1 | Mild (abdominal wall resistance or other signs of pain are elicited upon palpation of abdomen; moves slowly or is less responsive) | |
| 2 | Moderate (resists palpation; is reluctant to move when encouraged; does not lie on its side) | |
| 3 | Severe (persistent vocalization, howling and/or insomnia) | |
| Dehydration | 0 | None (<5%, no signs of dehydration) |
| 1 | Mild (5%, slight loss of skin elasticity) | |
| 2 | Moderate (6%‐8%, increased skin turgor, slightly delayed capillary refill time, dry mucous membranes, sunken eyes) | |
| 3 | Severe (≥10%, severely decreased skin turgor, delayed capillary refill time, deeply sunken eyes, severely dry mucous membranes) | |
| Fecal consistency | 0 | Normal (well formed) |
| 1 | Soft (slightly watery and poorly formed) | |
| 2 | Moderate (no form or runny) | |
| 3 | Watery (watery with no solids and pale) | |
| Blood in feces | 0 | Absent |
| 1 | Present |
Abbreviations: AP, acute pancreatitis; MCAI, modified clinical activity index.
a
Voluntary food intake.