TABLE 3.
Summary of multivariate Cox proportional hazard analyses in 175 dogs that received 3 fractions of 10 Gy SRT for sinonasal tumors.
Kaplan‐Meier (log rank) | Cox multivariate | |||||||
---|---|---|---|---|---|---|---|---|
Group | N | Median DSST (days) | 95% CI | P‐value | Coefficient | Hazard ratio (95% CI) | P‐value | |
Age | Low | 97 | 521 | 428‐614 | 0.047 | 0.1 | 1.1 (1.02‐1.18) | .01 |
High | 78 | 428 | 136‐308 | |||||
Body weight | .06 | |||||||
GTV volume (cc) | .96 | |||||||
PTV D mean (Gy) | .08 | |||||||
Brain D mean (Gy) | Low | 91 | 514 | 369‐659 | 0.014 | −0.26 | 0.77 (0.62‐0.95) | .01 |
High | 84 | 449 | 377‐521 | |||||
Brain D 98% (Gy) | 0.2 | |||||||
Brain D 10% (Gy) | .14 | |||||||
Brain V 10Gy (%) | Low | 87 | 592 | 456‐728 | 0.005 | 0.06 | 1.06 (1.02‐1.1) | .003 |
High | 88 | 441 | 376‐506 | |||||
Skin D max (Gy) | .06 | |||||||
Eye left D 98% (Gy) | .79 | |||||||
Eye right D 98% (Gy) | .62 | |||||||
Clinical signs of nervous system after SRT | No | 155 | 495 | 420‐569 | 0.002 | Reference group | .005 | |
Yes | 20 | 311 | 251‐371 | 0.8 | 2.2 (1.3‐4.0) |
Note: Bold indicates P<0.05.