TABLE 3.
BCAT expression and related studies in different types of cancer.
| Cancer type | BCAT expression | Description of relevant studies | References |
|---|---|---|---|
| Glioblastoma | High BCAT1 expression in IDHwt but was essentially absent in IDHmut | BCAT1 deletion combined with αKG is a new synthetic lethal method for the treatment of IDHwt GBM. The decrease in the expression of BCAT1 reduces the supply of glutamate, increases the dependence on glutaminase, and reduces tumor proliferation and invasion | Tönjes et al. (2013), Yi et al. (2021) |
| Liver cancer | High BCAT1 expression in HCC. | BCAT1 promotes HCC cell development and metastasis by activating the AKT signaling pathway and epithelial-mesenchymal transformation (EMT) | Ding et al. (2023) |
| Breast cancer | High BCAT1 expression in Breast cancer | BCAT1 knockdown may help reduce mTOR signaling and reduce the growth rate of breast cancer cell lines | Zhang and Han (2017) |
| Prostate Cancer | Low levels of BCAT activity | BCAT levels were elevated in healthy human prostate tissue relative to malignant tissue | Billingsley et al. (2014) |
| Colorectal Cancer | High BCAT1 expression in Colorectal Cancer | Long non-coding RNA (lncRNA) TMPO-AS1 can upregulate the expression of BCAT1 through miR-98-5p, promoting the progression of colorectal cancer cells | Xu et al. (2021), Ye et al. (2022) |
| Pancreatic ductal adenocarcinoma (PDAC) | High BCAT2 expression in PDAC. | BCAT2 knockdown significantly inhibited the proliferation of PDAC cells, reduced cellular fatty acid levels and associated with lipid synthesis | Lee et al. (2019) |
| Pancreatic cancer | High BCAT2 expression in Pancreatic cancer | Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth | Lei et al. (2020) |
| Gastric cancer | Low BCAT2 expression in Gastric cancer | Dysregulation of BCAT2 correlates with the overall survival time of gastric cancer patients | Zhang et al. (2022b) |
| Non-small cell lung cancer | High BCAT1 expression in Non-small cell lung cancer | BCAT1 promotes cell proliferation and invasion by regulating the Wnt signaling pathway | Lin et al. (2020) |