Table 2.
Prognostic factors of death in MPA patients
| Unadjusted | Age-adjusted | |||||
|---|---|---|---|---|---|---|
| Risk factors | Crude HR | 95% CI | P | Adjusted HR | 95% CI | P |
| Age (by year) | 1.110 | 1.072–1.151 | <0.001 | |||
| Smoking index | 1.080 | 0.974–1.174 | 0.135 | |||
| Alb (g/dL) | 1.001 | 0.999–1.001 | 0.054 | |||
| CRP (mg/dL) | 1.038 | 0.995–1.083 | 0.084 | |||
| BVAS at onset | 1.062 | 1.029–1.095 | <0.001 | 1.054 | 1.021–1.087 | 0.001 |
| Five-Factor Score 2009 | ||||||
| 2 (ref; ≤1) | 4.308 | 1.865–12.506 | <0.001 | 2.054 | 0.799–5.277 | 0.135 |
| ≥3 (ref; ≤1) | 3.578 | 1.339–11.217 | 0.010 | 1.541 | 0.538–4.412 | 0.42 |
| ≥3 (ref; 2) | 0.830 | 0.428–1.507 | 0.5535 | |||
| EUVAS categorization system | ||||||
| Early systemic (ref; localized) | 2.932 | 0.575–53.477 | 0.23 | |||
| Systemic (ref; localized) | 2.369 | 0.507–42.202 | 0.329 | |||
| Severe (ref; localized) | 4.692 | 0.959–84.637 | 0.058 | |||
| Systemic (ref; early systemic) | 0.808 | 0.423–1.644 | 0.54 | |||
| Severe (ref; early systemic) | 1.600 | 0.765–3.452 | 0.213 | |||
| Severe (ref; systemic) | 1.981 | 1.066–3.560 | 0.031 | 2.725 | 1.463–5.076 | 0.002 |
HR Hazard ratio, CI Confidence interval, ref Reference, MPA, Microscopic polyangiitis, Alb albumin, CRP C-reactive protein, BVAS Birmingham Vasculitis Activity Score, EUVAS European Vasculitis Study Group
The hazard ratios of death due to infection were derived from univariable and multivariable Cox regression analysis