TABLE 2.
Plasma | CNS | |||||||
---|---|---|---|---|---|---|---|---|
Concentration (ng/ml) | Corrected Measured Concentration (Mean ± S.D.; ng/ml) | Recovery (%) | Precision (% RSD) | Accuracy (% Bias) | Corrected Measured Concentration (Mean ± S.D.; ng/ml) | Recovery (%) | Precision (% RSD) | Accuracy (% Bias) |
5 | 4.28 ± 0.66 | 85.6 ± 13.2 | 15.5 | −14.5 | 5.51 ± 0.27 | 85.6 ± 13.2 | 4.87 | 10.24 |
8 | 9.00 ± 0.29 | 113 ± 36.3 | 3.23 | 12.6 | 8.44 ± 0.96 | 113 ± 36.3 | 11.4 | 5.54 |
80 | 84.9 ± 0.19 | 106 ± 0.24 | 0.23 | 6.18 | 79.5 ± 2.24 | 106 ± 0.24 | 2.81 | −0.68 |
800 | 815 ± 0.06 | 102 ± 0.01 | 0.01 | 1.87 | 764 ± 22.6 | 102 ± 0.01 | 2.95 | −4.48 |
1000 | 1047 ± 0.03 | 105 ± 0.00 | 0.00 | 4.68 | 993 ± 22.8 | 105 ± 0.00 | 2.30 | −0.71 |