TABLE 5.
Summary of pharmacokinetic parameters of agmatine after intravenous and oral administration Summary of pharmacokinetics parameters of agmatine after intravenous or oral administration in Sprague-Dawley rat. An ordinary one-way ANOVA with Tukey’s multiple comparison test was performed comparing t1/2 between doses and administration type. Results are presented as mean or mean ± S.E.M.
| Intravenous | Oral | |||
|---|---|---|---|---|
| Dose (mg/kg) | 3 | 30 | 100 | 300 |
| t1/2 (min) | 18.9 ± 1.25 | 14.9 ± 1.84 | 74.4 ± 11.1 | 117 ± 32.8a,b |
| Cmax (ng/ml) | 335 ± 130 | 23,930 ± 825 | 4730 ± 563 | 14,494 ± 7806 |
| tmax (min) | 10 | 5 | 23.6 ± 2.81 | 45 ± 4.59 |
| AUC0–∞ (ng/ml/min) | 35,075 ± 4510 | 421,956 ± 21,095 | 336,452 ± 34,544 | 122,2925 ± 347,552 |
| CL (ml/min/kg) | 98.6 ± 10.7 | 72.4 ± 3.29 | — | — |
| CL/F (ml/min/kg) | — | — | 317 ± 32.2 | 375 ± 179 |
| V (l/kg) | 2.66 ± 0.296 | 1.507 ± 0.135 | — | — |
| V/F (l/kg) | — | — | 32.2 ± 3.33 | 52.1 ± 13.8 |
| F (%) | — | — | 29.0 | 35.0 |
Dashes represent pharmacokinetic parameters not applicable to the defined treatment condition. aP < 0.05 from intravenous low dose.
bP < 0.05 from intravenous high dose.