TABLE 6.
Summary of pharmacokinetic parameters of agmatine in brain and spinal cord
Summary of pharmacokinetics parameters of agmatine intravenous administration in Sprague-Dawley rat plasma, spinal cord, and brain. Results are presented as pharmacokinetic parameters determined via sparse sampling.
| Plasma | Spinal Cord | Brain | |
|---|---|---|---|
| t1/2 (min) | 104 | 857 | 510 |
| CL (ml/min/kg) | 26.2 | — | — |
| V (l/kg) | 3.92 | — | — |
| tmax (min) | 15 | 120 | 15 |
| Cmax (ng/ml or g) | 59,278 | 814 | 3138 |
| AUC0–∞ (ng*hour/ml or g) | 63,658 | 18,718 | 25,246 |
| KP | — | 0.291 | 0.397 |