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. 2021 Oct 21;134(20):jcs259381. doi: 10.1242/jcs.259381

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© 2021. Published by The Company of Biologists Ltd

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Fig. 4. — LRRC23 localizes to axonemal radial spokes within sperm flagella. (A-H) Immunoelectron microscopy was conducted to evaluate sperm flagella from Lrrc23^+/+ and Lrrc23^Δ1/Δ1 mice. (A,C) Longitudinal and (B,D) cross-sections of the midpiece and principal piece labeled with anti-LRRC23. Gold particles (red arrowheads) were found to localize within the axoneme between the CP and the outer doublet microtubules, consistent with the location of the radial spokes. (E-H) Sperm flagella from Lrrc23^Δ1/Δ1 mice served as controls. (I) Representative images of an in situ proximity ligation assay using antibodies directed against LRRC23, RSPH22 and RSPH3 in sperm flagella from Lrrc23^+/+ and Lrrc23^Δ2/Δ2.