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. 2021 Oct 21;134(20):jcs259381. doi: 10.1242/jcs.259381

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© 2021. Published by The Company of Biologists Ltd

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Fig. 8. — Sterility of KO males is rescued by transgenic expression of LRRC23. (A) Schematic representation of generating the Lrrc23 transgene (Tg) mouse line. Transgene designed in which FLAG or 1D4-tagged LRRC23 are expressed as a fused protein under the testicular germ cell-specific Clgn promoter. (B) FLAG or 1D4-tagged LRRC23 expression in wild-type and KO mice carrying the Lrrc23 transgene was detected by western blotting. β-Actin was analyzed as a loading control. (C) Average litter size of Lrrc23 KO male mice expressing FLAG or 1D4-tagged Lrrc23 Tg. The average litter size (mean±s.d.) was 8.9±1.6 in wild-type males and 8.9±2.9 in FLAG or 1D4-tagged Lrrc23 rescued KO male mice. Data are mean±s.d. ND, P>0.05.