Figure 3. Longitudinal changes in epigenetic aging between the first and second blood samples among Black or non-Hispanic white older breast cancer survivors.

Linear mixed-effects models showing estimated longitudinal epigenetic aging from the first to second blood samples, collected between approximately 24- to 36-months and up to 60-months post-enrollment, in Black (n=7) and non-Hispanic white (n=69) breast cancer survivors based on (a) Horvath clock and (b) PhenoAge clock estimates. Models adjusted for chronological and epigenetic age at the first blood sample and comorbidities. Error bars represent 95% confidence intervals for each point estimate.