Table 4.

UAR of infants (N = 200 per age group) breastfed by mothers during real-world use of CBD and CBD-containing products

Parameter	> 0 to 7 days old	> 7 to 14 days old	> 14 to 30 days old	> 30 to 60 days old	> 60 to 365 days old
All concentrations
95th percentile of simulated breastfeeding infants ${\mathrm{A}\mathrm{U}\mathrm{C}}_{0-\mathrm{\tau }}$ (ng∙h/mL)	1.87	3.60	4.50	4.60	1.23
UARa	0.0024	0.0047	0.0058	0.0060	0.0016
Joint/blunt or edible exposure
95th percentile of simulated breastfeeding infants ${\mathrm{A}\mathrm{U}\mathrm{C}}_{0-\mathrm{\tau }}$ (ng∙h/mL)	0.22	0.40	0.69	0.50	0.25
UARa	0.00029	0.00047	0.00090	0.00065	0.00033
Oil or pipe exposure
95th percentile of simulated breastfeeding infants ${\mathrm{A}\mathrm{U}\mathrm{C}}_{0-\mathrm{\tau }}$ (ng∙h/mL)	3.23	35.25	17.09	4.56	4.00
UARa	0.0042	0.046	0.022	0.0059	0.0052

AUC area under the curve, CBD cannabidiol, UAR upper area under the curve ratio

^aUAR denominator consists of the simulated median ${\mathrm{A}\mathrm{U}\mathrm{C}}_{0-\mathrm{\tau }}$ based on the children aged 4–11 years from Devinsky et al. [13] receiving therapeutic doses for approved indications