Table 3. Mean differences in in vivo POD and bioactivity-based AED50 values.

The organ, number of chemicals with matched POD and ${\text{AED}}_{50}$ values, the type of in vivo POD (minimum LEL or HED), the type of ${\text{AED}}_{50}$ summary value being compared (mean or 5^th percentile), the mean difference, the p-value on this difference from paired randomization tests, and the lower and upper 95% confidence interval (CI) bounds around the mean difference, are shown in log₁₀-mg/kg/day values.

Organ	# Chemicals	In vivo POD (log10- mg/kg/day)	AED type (log10- mg/kg/day)	Mean difference, in vivo POD - AED (log10- mg/kg/day)	p-value	Lower CI bound	Upper CI bound
Liver	365	min LEL	mean AED	0.3203	<0.0001	0.1736	0.4670
Liver	365	min LEL	5th %-ile AED	1.3755	<0.0001	1.172	1.579
Kidney	194	min LEL	mean AED	0.5060	<0.0001	0.290	0.7223
Kidney	194	min LEL	5th %-ile AED	0.8586	<0.0001	0.608	1.110
Liver	365	min HED	mean AED	−0.3900	<0.0001	−0.5394	−0.2405
Liver	365	min HED	5th %-ile AED	0.6652	<0.0001	0.5013	0.8291
Kidney	194	min HED	mean AED	−0.2357	0.0245	−0.4418	−0.0295
Kidney	194	min HED	5th %-ile AED	0.1169	0.2953	−0.1027	0.3366