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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Comput Toxicol. 2023 Nov;28:1–17. doi: 10.1016/j.comtox.2023.100287

Table 4. Previous observations of concordance of findings in repeat dose studies.

Comparison
type		 Effect type Species Description of N %
Concordance		 Reference
Intraspecies (species-sex) concordance Site-specific carcinogenesis Male/Female site-specific carcinogenesis, average of within-mouse and within-rat 146 chemicals for rat; 159 chemicals for mouse 65-66 Haseman and Lockhart, 1993
https://doi.org/10.1289/ehp.9310150
Interspecies concordance Site-specific carcinogenesis, average for all sites Rat/Mouse 173 site-specific cancer positives in rat divided by positives in mouse, by chemical 35 Haseman and Lockhart, 1993
https://doi.org/10.1289/ehp.9310150
Interspecies concordance Site-specific carcinogenesis, average for all sites Mouse/Rat 167 site-specific cancer positives in mouse divided by positives in rat, by chemical 37 Haseman and Lockhart, 1993
https://doi.org/10.1289/ehp.9310150
Intraspecies concordance Carcinogen/non-carcinogen Mouse NCI/NTP studies vs. CPDB literature component; 70 chemicals 49 Gottmann et al., 2001
10.1289/ehp.01109509
Intraspecies concordance Carcinogen/non-carcinogen Rat NCI/NTP studies vs. CPDB literature component; 71 chemicals 62 Gottmann et al., 2001
10.1289/ehp.01109509
Interspecies Carcinogen/non-carcinogen Rat vs. Mouse NTP studies, 313 chemicals 74.4 Huff et al., 1991
10.1289/ehp.9193247