Table 2.
Model performance for CHD and CVD events with addition of Lp(a) level to the PCE.
| CVD | ||||
|---|---|---|---|---|
| Overall | Low risk (<7.5%) | Intermediate risk (7.5-<20%) | High risk (≥20%) | |
| C-index (SE) | ||||
| PCE alone | 0.739 (0.011) |
0.659 (0.035) |
0.594 (0.022) |
0.592 (0.020) |
| PCE + Lp(a) > 50 mg/dL | 0.739 (0.011) |
0.683 (0.033) |
0.595 (0.022) |
0.609 (0.019) |
| PChange | 0.000 | +0.024 | +0.001 | +0.017 |
| Continuous NRI (95% CI) | ||||
| Overall |
0.0963
(0.0158, 0.1953) |
0.2999
(0.0876, 0.5525) |
0.0747 (−0.0130, 0.2283) |
0.1249
(0.0032, 0.2437) |
| Events |
−0.5114
(−0.5851, −0.4122) |
−0.3328 (−0.5258, 0.0462) |
0.6543 (−0.6059, 0.7898) |
−0.4711
(−0.5818, −0.3058) |
| Non-events |
0.6077
(0.5895, 0.6269) |
0.6327
(0.5949, 0.6626) |
−0.5795 (−0.6111, 0.6073) |
0.5959
(0.5460, 0.6427) |
| CHD | ||||
| Overall | Low risk (<7.5%) | Intermediate risk (7.5-<20%) | High risk (≥20%) | |
| C-index (SE) | ||||
| PCE alone | 0.735 (0.014) |
0.649 (0.046) |
0.607 (0.026) |
0.573 (0.026) |
| PCE + Lp(a) > 50 mg/dL | 0.737 (0.013) |
0.687 (0.044) |
0.609 (0.026) |
0.598 (0.024) |
| Change | +0.002 | +0.038 | +0.002 | +0.025 |
| Continuous NRI (95% CI) | ||||
| Overall |
0.1248
(0.0321, 0.2405) |
0.4432
(0.0717, 0.7827) |
0.0667
(0.0001, 0.2337) |
0.1295
(0.0052, 0.2661) |
| Events |
−0.4816
(−0.5691, −0.3748) |
−0.1889 (−0.5583, 0.1317) |
0.6488 (−0.5839, 0.8066) |
−0.4597
(−0.5891, −0.2872) |
| Non-events |
0.6064
(0.5879, 0.6297) |
0.6321
(0.6035, 0.6603) |
−0.5821 (−0.6108, 0.6158) |
0.5892
(0.5372, 0.6352) |
NRI = Net Reclassification Improvement. PCE = Pooled Cohort Equations.