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[Preprint]. 2023 Nov 10:2023.11.07.564025. [Version 1] doi: 10.1101/2023.11.07.564025

Figure 5. Abcd1-null mice induced with CPZ/EAE exhibit abundant perivascular infiltration of macrophages, T-cells, and B-cells.

Figure 5.

(A) The cartoons illustrate the spatial distribution of perivascular cuffs in a representative mouse, as determined by DAPI staining, across experimental arms. Representative histologic images depict perivascular infiltration of (B) macrophage/microglia (CD68 staining) (C) T cells (CD3e staining) and B cells (B220 staining) in the Abcd1y/− mice induced with CPZ/EAE similar to human cALD. Scale bars, 50 µm. Quantitative assessment shows high levels of (D) total immune cells, (E) macrophages/microglia, (F) T cells, and (G) B cells in Abcd1y/− mice induced with CPZ/EAE. Bar graphs display the mean ± SD. Brown-Forsythe Welch ANOVA test determined the significance between the groups. CPZ: cuprizone; EAE: experimental autoimmune encephalomyelitis.