Table 1: Bone Parameters and Serum Markers.

FNDC5 KO female and male mice have opposite responses to a low-calcium diet compared to WT female and male mice where female KO mice are protected but male KO mice have greater bone loss than WT.

		% Change in female		% Change in male
	Change	WT	KO	WT	KO
Bone Area	Decrease	13%	7% *	2%	13% *
Bone Area Fraction	Decrease	17%	11% *	7%	23% *
Cortical Thickness	Decrease	19%	13% *	4%	15% *
Osteoclast Number/Bone Perimeter	Increase	125%	127%	170%	336% *
TRAP-positive Osteocytes	Increase	180%	290% *	85%	388% *
Osteocyte Lacunar Area	Increase	38%	16% *	60%	89% *
Serum PTH	Increase	150%	75% *	70%	164% *
Serum RANKL	Increase	100%	118%	119%	130%

Percentage changes in different bone and serum parameters of WT and KO female and male mice with a 2-week low-calcium diet.

^*= p<0.05 compared to WT.