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[Preprint]. 2023 Nov 6:2023.11.06.565899. [Version 1] doi: 10.1101/2023.11.06.565899

Figure 6: Properties of low-mosaic excitatory and inhibitory clones in the dorsal cortex.

Figure 6:

(A) A schematic depiction of the motivation behind the minimum-AAF statistic, used to assess if a variant shared between two cell types occurred in a progenitor before an early or late divergence of the cell types. (B) Number and minimum AAF (from region-averaged WGS) of variants found detected across cell types annotated within the 10X data. Estimates were aggregated across all variants detected with 10X data from both brains. (AC WGS AAF distributions of variants found detected in excitatory neurons, inhibitory neurons, and microglia. (D) Empirical Bayes estimates of the proportion of excitatory and inhibitory neurons found in subsets (as depicted in (B)). Only subsets with ¿ 10 cells were analyzed. (E) UMAP annotations of inhibitory neurons (marked in red) sharing variants at ¡2% AAF (¡4% MF) with excitatory neurons (not marked), along with the expression level (number of UMIs) of different types of inhibitory neuron markers. (F) UMAPs with variants marked for variants found exclusively shared amongst excitatory neurons (all layers) (left panel) and for two variants shared between an upper-layer neuron and subsets of all-layer excitatory neurons (right panel).