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[Preprint]. 2024 Apr 1:2023.11.07.566110. Originally published 2023 Nov 8. [Version 3] doi: 10.1101/2023.11.07.566110

Fig. 4: vgRNA clusters are encapsulated in membranes of remodeled ER.

Fig. 4:

a, Representative confocal images of SARS-CoV-2 infected cells indicate an appearance of dense perinuclear foci of Sec61β ER labeling (green) at 24 hpi that colocalizes with vgRNA and nsp3. b, SR images reveal concentric organization of Sec61β around vgRNA, dsRNA and nsp12, and colocalization of Sec61β with nsp3. c, Bivariate pair-correlation functions indicate anti-correlation of Sec61β with vgRNA and dsRNA and association of Sec61β with nsp3. Scale bars, 20 μm (a) and 1 μm (b). Dashed lines in b indicate the boundary of the cell nucleus.