Table 1. Distribution of overall cohort.

We use approximately 80% (385,541) individuals in the training, and 79,119 in the testing set, of which approximately 45% represent members of the general practice primary care data. Of note, low genomic risk connotes individuals in the lowest (<20%) of genomic risk by PRS percentile, intermediate (20–80%) PRS percentile, and high denotes >80% PRS percentile.

	Low (N=96235)	Intermediate (N=288563)	High (N=95840)	Overall (N=480638)
Sex
Female	51958 (54.0%)	156570 (54.3%)	52125 (54.4%)	260653 (54.2%)
Male	44277 (46.0%)	131993 (45.7%)	43715 (45.6%)	219985 (45.8%)
Birthdate
Median [Min, Max]	1950 [1940, 1970]	1950 [1930, 1970]	1950 [1940, 1970]	1950 [1930, 1970]
Age First Enrolled in NHS
Mean (SD)	29.2 (13.2)	29.2 (13.2)	29.1 (13.2)	29.2 (13.2)
Median [Min, Max]	24.5 [18.0, 78.6]	24.3 [18.0, 78.3]	24.2 [18.0, 79.1]	24.3 [18.0, 79.1]
Years Followed
Mean (SD)	29.5 (8.05)	29.5 (8.03)	29.3 (8.01)	29.4 (8.03)
Median [Min, Max]	30.6 [0.375, 45.5]	30.6 [0.843, 47.6]	30.3 [1.36, 44.8]	30.5 [0.375, 47.6]
Develop Hypertension
No	63687 (66.2%)	174497 (60.5%)	52002 (54.3%)	290186 (60.4%)
Yes	32548 (33.8%)	114066 (39.5%)	43838 (45.7%)	190452 (39.6%)
Develop Coronary Disease
No	89929 (93.4%)	258215 (89.5%)	79034 (82.5%)	427178 (88.9%)
Yes	6306 (6.6%)	30348 ( 10.5%)	16806 ( 17.5%)	53460 ( 11.1%)
Develop Hyperlipidemia
No	79046 (82.1%)	221300 (76.7%)	66698 (69.6%)	367044 (76.4%)
Yes	17189 (17.9%)	67263 (23.3%)	29142 (30.4%)	113594 (23.6%)
Current Smoker
No	86517 (89.9%)	258134 (89.5%)	85315 (89.0%)	429966 (89.5%)
Yes	9718 (10.1%)	30429 ( 10.5%)	10525 ( 11.0%)	50672 ( 10.5%)
Proportion White
Yes	82842 (86.1%)	251780 (87.3%)	82479 (86.1%)	417101 (86.8%)
General Practice Registry Members
Not Member	52539 (54.6%)	155429 (53.9%)	51319 (53.5%)	259287 (53.9%)
Member	43696 (45.4%)	133134 (46.1%)	44521 (46.5%)	221351 (46.1%)