Table 2.
Top SNPs from meta-analysis
| CHR | BP | SNP ID | Effect allele | Nearest gene | Effect allele frequency | OR | CI | P-value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tracking Parkinson’s and Oxford Discovery | AMP-PD | ||||||||||
| LBD - D | LBD - ND | LBD - D | LBD - ND | ||||||||
| 19 | 44908684 | rs429358 | C | APOE | 0.2 | 0.13 | 0.27 | 0.13 | 1.358 | 1.308-1.410 | 3.25E-57 |
| 4 | 89870668 | rs7668531 | G | MMRN1 | 0.43 | 0.47 | 0.43 | 0.49 | 1.39 | 1.267 - 1.525 | 3.25E-12 |
| 12 | 40141971 | rs17442721 | G | LINC02555 | 0.01 | 0.02 | 0.02 | 0.07 | 0.427 | 0.32 - 0.57 | 1.44E-08 |
| 11 | 82697450 | rs11233271 | G | MIR4300HG | 0.1 | 0.12 | 0.11 | 0.13 | 1.482 | 1.284 - 1.709 | 6.78E-08 |
| 8 | 52583054 | G | ALKAL1 | 0.14 | 0.13 | 0.15 | 0.14 | 1.388 | 1.217 - 1.582 | 8.78E-07 | |
Independent lead SNPs identified by LOCUSZOOM
Genome coordinates are in build GRCh38
Abbreviations: BP = base pair, chr = chromosome, CI = Confidence Interval, OR = Odds Ratio, SNP = Single Nucleotide Polymorphism