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[Preprint]. 2023 Nov 10:2023.11.09.23298321. [Version 1] doi: 10.1101/2023.11.09.23298321

Figure 1. Expression of RB1 and survival associations across ovarian cancer histotypes.

Figure 1.

(A) Representative images of immunohistochemical detection of RB1 expression in ovarian carcinoma tissues, showing examples of the three most common expression patterns: retained, lost and subclonal loss. (B) Proportion of patients with loss or retention of RB1 protein expression in tumour samples by ovarian cancer histotypes. Chi-square P value reported for difference in proportions across all histotypes. HGSC, tubo-ovarian high-grade serous carcinoma; LGSC, low-grade serous carcinoma; MOC, mucinous ovarian cancer; ENOC, endometrioid ovarian cancer; CCOC, clear cell ovarian cancer. (C) Boxplots show RB1 mRNA expression (NanoString) by RB1 protein expression status; lines indicate median and whiskers show range (Mann-Whitney test P value reported). Kaplan-Meier analysis of overall survival in patients diagnosed with HGSC (D) and ENOC (E) stratified by tumour RB1 expression. (F) Loss of RB1 tumour expression is more common in germline BRCA1 and BRCA2 mutation carriers than retained RB1 expression. Chi-square P value is reported. (G) Kaplan-Meier estimates of overall survival in HGSC patients by combined germline BRCA and tumour RB1 expression status.