Table 2.
Multivariate adjusted association* of D3Cr muscle mass or MR thigh muscle volume with various strength and performance measures in older men and women (beta coefficient per sex-specific standard deviation decrement**).
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| D3Cr muscle mass | MR thigh muscle volume | |||||||||
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| Men | Women | p-int | Men | Women | p-int*** | |||||
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| N | Beta coefficient (95% CI) | N | Beta coefficient (95% CI) | N | Beta coefficient (95% CI) | N | Beta coefficient (95% CI) | |||
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| Grip strength (kg) | 335 | −1.1 (−2.0, −0.1) | 472 | −0.3 (−0.8, 0.3) | 0.188 | 314 | −2.5 (−3.7, −1.3) | 449 | −1.3 (−1.9, −0.6) | 0.492 |
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| 1-RM leg strength (kg) | 327 | −14 (−21, −7) | 458 | −4 (−8, −1) | 0.003 | 307 | −32 (−40, −24) | 435 | −20 (−24, −16) | 0.139 |
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| Peak leg power (Watts) | 327 | −44 (−61, −26) | 458 | −12 (−20, −5) | <0.001 | 307 | −89 (−110, −68) | 435 | −40 (−50, −31) | 0.007 |
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| 400m walk speed (m/s) | 337 | −0.04 (−0.05, −0.02) | 476 | −0.01 (−0.02, 0.00) | 0.019 | 316 | −0.05 (−0.08, −0.03) | 453 | −0.04 (−0.06, −0.02) | 0.449 |
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| Expanded SPPB overall score (0–4) | 337 | −0.11 (−0.17, −0.05) | 474 | −0.06 (−0.11, −0.02) | 0.506 | 316 | −0.16 (−0.23, −0.08) | 451 | −0.17 (−0.22, −0.11) | 0.672 |
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| 4m walk speed (m/s) | 337 | −0.02 (−0.05, 0.00) | 476 | −0.01 (−0.03, 0.01) | 0.446 | 316 | −0.04 (−0.07, −0.01) | 453 | −0.04 (−0.06, −0.02) | 0.582 |
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| Chair stands per 10 seconds | 337 | −0.24 (−0.39, −0.08) | 475 | −0.16 (−0.27, −0.05) | 0.880 | 316 | −0.42 (−0.62, −0.22) | 452 | −0.36 (−0.50, −0.22) | 0.770 |
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| Four square step test time (sec) | 308 | 0.35 (0.03, 0.68) | 441 | 0.37 (0.10, 0.64) | 0.406 | 291 | 0.59 (0.21, 0.97) | 419 | 0.71 (0.38, 1.05) | 0.242 |
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| Stair climb total time (sec) | 328 | 1.27 (0.52, 2.01) | 457 | 1.02 (0.33, 1.70) | 0.957 | 307 | 1.43 (0.53, 2.33) | 434 | 2.21 (1.35, 3.07) | 0.482 |
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| Narrow walk speed (m/s) | 303 | −0.01 (−0.04, 0.02) | 438 | −0.02 (−0.05, −0.00) | 0.558 | 285 | −0.06 (−0.10, −0.02) | 416 | −0.05 (−0.08, −0.03) | 0.493 |
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| VO2peak (mL/min) | 322 | −79 (−120, −38) | 444 | −30 (−50, −10) | 0.016 | 304 | −217 (−263, −171) | 424 | −111 (−135, −87) | 0.010 |
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*
models adjusted for age, site, weight, height, activity level, multimorbidity index
**
sex specific standard deviations: D3Cr muscle mass: men 6.13 kg, women 4.14 kg; MR thigh muscle volume: men: 1.58 L, women, 1.10 L
***
interaction models include muscle mass or volume, sex, and muscle mass or volume*sex.
Beta coefficient (95% CI) shown in bold if p<0.05