Table 3.
Multivariate adjusted association* (odds ratio, 95% CI per sex-specific standard deviation (SD) decrement**) of D3Cr muscle mass or MR thigh muscle volume with dichotomous (self-reported and objective) measures of function in older men and women.
| Task or scale | D3Cr muscle mass | MR thigh muscle volume | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Men | Women | p-int*** | Men | Women | p-int*** | |||||
| N of events (%) | Odds ratio (95% CI) | N of events (%) | Odds ratio (95% CI) | N of events (%) | Odds ratio (95% CI) | N of events (%) | Odds ratio (95% CI) | |||
| Self-reported mobility limitation | 21 (6.3) | 1.71 (0.94, 3.10) | 46 (9.8) | 0.96 (0.68, 1.36) | 0.061 | 20 (6.4) | 2.21 (1.05, 4.65) | 44 (9.8) | 1.65 (1.01, 2.68) | 0.547 |
| Functional limitation | 65 (20.1) | 1.68 (1.15, 2.46) | 140 (31.3) | 0.89 (0.70, 1.13) | 0.021 | 57 (18.5) | 2.44 (1.48, 4.05) | 136 (32.1) | 1.29 (0.94, 1.76) | 0.268 |
| MAT-sf limitation (score <60) | 31 (9.7) | 1.98 (1.16, 3.38) | 93 (20.0) | 1.94 (1.41, 2.67) | 0.936 | 26 (8.7) | 1.84 (0.93, 3.61) | 87 (19.7) | 2.56 (1.69, 3.87) | 0.588 |
| SPPB limitation (score ≤8) | 41 (12.2) | 1.92 (1.20, 3.08) | 75 (15.8) | 1.27 (0.94, 1.72) | 0.190 | 39 (12.3) | 1.49 (0.85, 2.60) | 71 (15.7) | 1.76 (1.17, 2.63) | 0.978 |
| Poor balance (score <61 seconds) | 57 (20.4) | 2.32 (1.51, 3.55) | 97 (20.4) | 1.21 (0.91, 1.59) | 0.342 | 56 (17.7) | 1.90 (1.17, 3.08) | 95 (21.0) | 1.91 (1.32, 2.75) | 0.357 |
*
Models adjusted for age, site, weight, height, activity level, multimorbidity index
**
D3Cr muscle mass SD: men 6.13 kg women 4.14 kg; MRI thigh muscle volume SD: men 1.58 L, women: 1.10 L.
***
interaction models include muscle mass or volume, sex, and muscle mass or volume*sex.
Odds ratio (95% CI) shown in bold if p<0.05. N of events (%) is based on the total number of participants in each model.