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[Preprint]. 2023 Nov 7:rs.3.rs-2802998. [Version 1] doi: 10.21203/rs.3.rs-2802998/v1

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Extended Data Figure 4: — a-c, Bulk RNA sequencing analyses of day 15 tNGFR-purified CD8⁺ CD19.28ζ CAR T cells overexpressing tNGFR (black), TCF1 (red), or FOXO1 (blue) (n = 3 donors). a, Unbiased principal component analysis (PCA). b, Venn diagram showing the number of unique and shared differentially expressed genes (DEGs) in TCF1_OE and FOXO1_OE cells compared to tNGFR cells (adjusted P < 0.05 with log2(fold change) 0.5). c, Heatmap and hierarchical clustering of DEGs. Genes of interest are demarcated and colored based on the condition in which they’re upregulated.