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[Preprint]. 2023 Nov 6:rs.3.rs-3429258. [Version 1] doi: 10.21203/rs.3.rs-3429258/v1

Figure 7. NRG1 stimulated axon sorting and PTN increased the regeneration of mid-size axons.

Figure 7.

A, Representative electron microscopy images showing axons within Remak bundles. Axons, myelin, Schwann cells are labeled by a star symbol, M, and Sch, respectively. Remak bundles are highlighted by yellow dashed circles. Red arrowheads indicate large unmyelinated axons sorted out of the Remak bundles. Scale bar: 5μm. B, NRG1 significantly reduced the number of abnormal axon bundles, indicating the positive effect on axon sorting. C, Quantification of the diameter of myelinated and unmyelinated axons present in the distal end of the regenerated nerves. D, Frequency distribution of the axon diameter. PTN-NRG1 treatment increased the number of axons above 3 μm in diameter, comparable to that of the autograft group. *, p<0.05; ns, p>0.05.