Table 3.

Longitudinal analysis of effect of anemia severity

EF outcome	n used	Low HGB (1st to < 5th pctl)		Very low HGB (< 1st pctl)		ESA use
		Estimate (95% CI)	p-value	Estimate (95% CI)	p-value	Estimate (95% CI)	p-value
Errors of omission	1074	2.03 (− 0.52, 4.57)	0.12	1.12 (− 1.42, 3.66)	0.39	− 1.76 (− 5.14, 1.61)	0.31
Errors of commission	1081	− 0.68 (− 2.53, 1.18)	0.47	− 0.47 (− 2.35, 1.41)	0.63	0.27 (− 2.27, 2.81)	0.84
Tower total achievement	986	− 0.07 (− 0.63, 0.49)	0.82	− 0.07 (− 0.62, 0.47)	0.79	0.11 (− 0.67, 0.88)	0.78
Digit span total	767	− 0.53 (− 1.06, − 0.00)	0.048	− 0.26 (− 0.81, 0.30)	0.36	0.51 (− 0.26, 1.28)	0.19
Category fluency	488	− 0.50 (− 1.46, 0.47)	0.31	− 0.52 (− 1.49, 0.44)	0.29	0.37 (− 1.31, 2.04)	0.66
Category switching	486	0.12 (− 0.85, 1.10)	0.80	− 0.22 (− 1.16, 0.72)	0.64	0.94 (− 0.67, 2.55)	0.25
Total switching	485	0.29 (− 0.61, 1.19)	0.53	− 0.39 (− 1.25, 0.48)	0.37	0.19 (− 1.29, 1.66)	0.80
Design fluency	483	− 0.41 (− 1.25, 0.43)	0.33	0.39 (− 0.43, 1.22)	0.35	0.10 (− 1.25, 1.46)	0.88
Design switching	482	0.11 (− 0.74, 0.96)	0.80	0.34 (− 0.49, 1.17)	0.42	0.02 (− 1.35, 1.38)	0.98
Color-word inhibition/switching	476	0.06 (− 0.76, 0.88)	0.88	− 1.33 (− 2.16, − 0.51)	0.002	0.77 (− 0.67, 2.20)	0.29
BRI	1371	0.74 (− 0.77, 2.26)	0.33	− 0.09 (− 1.67, 1.49)	0.91	1.71 (− 0.41, 3.83)	0.11
MI	1366	0.41 (− 1.12, 1.93)	0.60	− 0.55 (− 2.16, 1.05)	0.50	0.76 (− 1.41, 2.93)	0.49
GEC	1368	0.59 (− 0.92, 2.10)	0.45	− 0.44 (− 2.04, 1.15)	0.58	1.23 (− 0.93, 3.39)	0.26

^1.Models adjusted for age, sex, glomerular diagnosis, duration of CKD, eGFR, proteinuria level, maternal education, hypertension, abnormal birth history, and history of seizures