Table 3.

Network topology parameters.

NO.	Name	Degree	Closeness centrality	Betweenness centrality	Node property
1	MAPK1	109	0.523	0.241	Protein target
2	AKT1	101	0.504	0.179	Protein target
3	PIK3R1	98	0.501	0.156	Protein target
4	TNF	62	0.434	0.119	Protein target
5	IL6	48	0.410	0.059	Protein target
6	NOS3	37	0.394	0.138	Protein target
7	TGFB1	34	0.374	0.025	Protein target
8	INS	28	0.366	0.015	Protein target
9	PTEN	27	0.366	0.015	Protein target
10	CACNA1C	25	0.358	0.023	Protein target
11	INSR	24	0.361	0.011	Protein target
12	quercetin	13	0.456	0.021	Compound
13	kaempferol	6	0.422	0.007	Compound
14	daidzein	6	0.374	0.008	Compound
15	naringenin	5	0.402	0.007	Compound
16	Lauric Acid	5	0.402	0.003	Compound
17	GLY	5	0.284	0.020	Compound
18	gamma-aminobutyric acid	5	0.410	0.023	Compound
19	N-Methyltyramine	4	0.417	0.025	Compound
20	Jurubine	3	0.325	0.004	Compound
21	alpha-humulene	3	0.316	0.005	Compound
22	AGE-RAGE signaling pathway in diabetic complications	23	0.488	0.055	KEGG
23	Diabetic cardiomyopathy	15	0.443	0.033	KEGG
24	Insulin resistance	14	0.456	0.023	KEGG
25	Alzheimer disease	14	0.427	0.013	KEGG
26	Type II diabetes mellitus	13	0.449	0.016	KEGG
27	nonalcoholic fatty liver disease	11	0.407	0.007	KEGG
28	FoxO signaling pathway	10	0.405	0.004	KEGG
29	Adipocytokine signaling pathway	9	0.340	0.006	KEGG
30	MAPK signaling pathway	8	0.406	0.004	KEGG
31	AMPK signaling pathway	8	0.371	0.003	KEGG
32	Insulin signaling pathway	8	0.405	0.008	KEGG
33	PI3K-Akt signaling pathway	8	0.427	0.008	KEGG
34	Pathways in cancer	8	0.405	0.003	KEGG
35	HQ	22	0.366	0.043	TCM
36	CP	18	0.347	0.096	TCM
37	BZ	15	0.294	0.019	TCM

BZ = Baizhu, CP = Chenpi, HQ = Huangqi, KEGG = Kyoto Encyclopedia of Genes and Genomes, TCM = Traditional Chinese medicine.