Table 1.
Relationships between the expression of TC1, Chibby, β-catenin and clinicopathological features in LSCC.
| Clinicopathological features | n | TC1 expression | P value | Chibby expression | P value | β-catenin expression | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Negative (%) | Positive (%) | Negative (%) | Positive (%) | Normal (%) | Abnormal (%) | |||||
| Sex | ||||||||||
| Male | 51 | 9 (17.65) | 42 (82.35) | 1.000* | 28 (54.90) | 23 (45.10) | .218* | 15 (29.41) | 36 (70.59) | 1.000* |
| Female | 2 | 0 (0.00) | 2 (100.00) | 0 (0.00) | 2 (100.00) | 0 (0.00) | 2 (100.00) | |||
| Agea | ||||||||||
| <66 | 25 | 4 (16.00) | 21 (84.00) | 1.000* | 14 (56.00) | 11 (44.00) | .662# | 7 (28.00) | 18 (72.00) | .963# |
| ≥66 yr | 28 | 5 (17.86) | 23 (82.14) | 14 (50.00) | 14 (50.00) | 8 (28.57) | 20 (71.43) | |||
| Smoking | ||||||||||
| No | 15 | 2 (13.33) | 13 (86.67) | 1.000* | 7 (46.67) | 8 (53.33) | .572# | 3 (20.00) | 12 (80.00) | .510* |
| Yes | 38 | 7 (18.42) | 31 (81.58) | 21 (55.26) | 17 (44.74) | 12 (31.58) | 26 (68.42) | |||
| Drinking | ||||||||||
| No | 20 | 2 (10.00) | 18 (90.00) | .456* | 10 (50.00) | 10 (50.00) | .748# | 7 (35.00) | 13 (65.00) | .399# |
| Yes | 33 | 7 (21.21) | 26 (78.79) | 18 (54.55) | 15 (45.45) | 8 (24.24) | 25 (75.76) | |||
| Tumor site | ||||||||||
| Glottic | 29 | 8 (27.59) | 21 (72.41) | .031* | 14 (48.28) | 15 (51.72) | .465# | 13 (44.83) | 16 (55.17) | .003# |
| Non-glottic | 24 | 1 (4.17) | 23 (95.83) | 14 (58.33) | 10 (41.67) | 2 (8.33) | 22 (91.67) | |||
| TNM stage | ||||||||||
| I + II | 25 | 8 (32.00) | 17 (68.00) | .009* | 12 (48.00) | 13 (52.00) | .506# | 12 (48.00) | 13 (52.00) | .003# |
| III + IV | 28 | 1 (3.57) | 27 (96.43) | 16 (57.14) | 12 (42.86) | 3 (10.71) | 25 (89.29) | |||
| T stage | ||||||||||
| 1 + 2 | 27 | 8 (29.63) | 19 (70.37) | .024* | 14 (51.85) | 13 (48.15) | .884# | 12 (44.44) | 15 (55.56) | .008# |
| 3 + 4 | 26 | 1 (3.85) | 25 (96.15) | 14 (53.85) | 12 (46.15) | 3 (11.54) | 23 (88.46) | |||
| Lymphatic metastasis | ||||||||||
| No | 45 | 9 (20.00) | 36 (80.00) | .324* | 22 (48.89) | 23 (51.11) | .256* | 13 (28.89) | 32 (71.11) | 1.000* |
| Yes | 8 | 0 (0.00) | 8 (100.00) | 6 (75.00) | 2 (25.00) | 2 (25.00) | 6 (75.00) | |||
| Lymphovascular invasion | ||||||||||
| No | 38 | 9 (23.68) | 29 (76.32) | .047* | 19 (50.00) | 19 (50.00) | .511# | 14 (36.84) | 24 (63.16) | .041* |
| Yes | 15 | 0 (0.00) | 15 (100.00) | 9 (60.00) | 6 (40.00) | 1 (6.67) | 14 (93.33) | |||
| Perineurial invasion | ||||||||||
| No | 44 | 9 (20.45) | 35 (79.55) | .329* | 23 (52.27) | 21 (47.73) | 1.000* | 15 (34.09) | 29 (65.91) | .047* |
| Yes | 9 | 0 (0.00) | 9 (100.00) | 5 (55.56) | 4 (44.44) | 0 (0.00) | 9 (100.00) | |||
| Differentiation | ||||||||||
| Highly | 20 | 7 (35.00) | 13 (65.00) | .019* | 9 (45.00) | 11 (55.00) | .374# | 11 (55.00) | 9 (45.00) | .001# |
| Moderately + Poorly | 33 | 2 (6.06) | 31 (93.94) | 19 (57.58) | 14 (42.42) | 4 (12.12) | 29 (87.88) | |||
LSCC = laryngeal squamous cell carcinoma, TC1 = thyroid cancer 1, TNM = tumor node metastases.
a
The patients were grouped according to median age (66 yr).
# Statistical significance was determined using the Χ2 test.
*
Statistical significance was determined using the Fisher exact test in 2 × 2 table because the theoretical frequency was smaller than 5. The results were showed by number (%). P value of <.05 was considered statistically significant.