Table 1. Participant characteristics a .
| SCD |
Control |
p-value |
|
| N of participants | 12 | 14 | - |
| Age (years) | 11.2 (10.6, 13.1) | 11.5 (8.9, 12.2) | 0.661 |
| Sex (N; % Female) | 6; 50% | 8; 57.1% | - |
| Weight (kg) | 40 (34, 47) | 44 (30, 52) | 0.931 |
| Height (cm) | 144 (142, 155) | 153 (141, 160) | 0.624 |
| Systolic blood pressure (mmHg) | 111 (103, 117) | 91 (65, 118) | 0.290 |
| Diastolic blood pressure (mmHg) | 64 (60, 68) | 58 (65, 66) | 0.218 |
| Mean blood pressure (mmHg) | 80 (78, 83) | 74 (73, 81) | 0.217 |
| Oxygen saturation (%) | 99 (97, 100) | 97 (96, 98) | 0.220 |
| AA (N; %) | 0; 0% | 16; 100% | - |
| SS (N; %) | 11; 100% | 0; 0% | - |
| Hemoglobin (g/dL) | 8.9 (7.9, 9.8) | - | - |
| Hematocrit (%) | 25 (22, 28) | - | - |
| Reticulocytes (1E10/L) | 18 (15, 27) | - | - |
| Fetal hemoglobin (%) | 10 (7, 15) | - | - |
| Sickle hemoglobin (%) | 86 (81, 90) | - | - |
| Hydroxyurea only (N; %) | 8; 66.7% | - | - |
| Voxelotor only (N; %) | 1; 8.3% | - | - |
| Hydroxyurea and Voxelotor (N; %) | 2; 16.7% | - | - |
a
Data are reported as median (interquartile range) or count (percentage) for the SCD and control participants with data that was included in the final analysis for either breath-hold or resting state paradigms. p-values estimated by Wilcoxon rank sum test.