Table 10.
Pulmonary hypertension classification based on 2015 and 2022 ESC/ERS guideline definitions
| mPAP <21 mmHg (n = 968) | mPAP 21–24 mmHg (n = 689) | mPAP ≥25 mmHg (n = 1272) | Overall (n = 2929) | |
|---|---|---|---|---|
| 2015 ESC/ERS guideline definition | ||||
| Pre-capillary pulmonary hypertensiona | 0 (0%) | 0 (0%) | 757 (59.5%) | 757 (25.8%) |
| Isolated post-capillary pulmonary hypertensionb | 0 (0%) | 0 (0%) | 395 (31.1%) | 395 (13.5%) |
| Combined post-capillary pulmonary hypertensionc | 0 (0%) | 0 (0%) | 120 (9.4%) | 120 (4.1%) |
| No pulmonary hypertension | 968 (100%) | 689 (100%) | 0 (0%) | 1657 (56.6%) |
| 2022 ESC/ERS guideline definition | ||||
| Unclassified pulmonary hypertensiond | 0 (0%) | 237 (34.4%) | 43 (3.4%) | 280 (9.6%) |
| Pre-capillary pulmonary hypertensiona | 0 (0%) | 367 (53.3%) | 714 (56.1%) | 1081 (36.9%) |
| Isolated post-capillary pulmonary hypertensionb | 0 (0%) | 78 (11.3%) | 175 (13.8%) | 253 (8.6%) |
| Combined post-capillary pulmonary hypertensionc | 0 (0%) | 7 (1.0%) | 340 (26.7%) | 347 (11.8%) |
| No pulmonary hypertension | 968 (100%) | 0 (0%) | 0 (0%) | 968 (33.1%) |
a2015 ESC/ERS criteria; mPAP ≥25 mmHg, PAWP ≤15 mmHg. 2022 ESC/ERS criteria; mPAP >20 mmHg, PVR >2 WU, PAWP ≤15 mmHg.
b2015 ESC/ERS criteria; mPAP ≥25 mmHg, PAWP >15 mmHg, DPG, diastolic pulmonary gradient <7 mmHg and/or PVR ≤3 WU. 2022 ESC/ERS criteria; mPAP >20 mmHg, PVR ≤2 WU, PAWP >15 mmHg.
c2015 ESC/ERS criteria; mPAP ≥25 mmHg, PAWP >15 mmHg, DPG ≥7 mmHg and/or PVR >3 WU. 2022 ESC/ERS criteria; mPAP >20 mmHg, PVR >2 WU, PAWP >15 mmHg.
d2022 ESC/ERS criteria; mPAP >20 mmHg PVR ≤2 WU, PAWP ≤15 mmHg.